Molecular Manipulation & Analysis Lasers

Flow Cytometry Cell Substructures

What are Molecular Manipulation & Analysis Lasers?

Molecular manipulation & analysis lasers in the field of biophotonics are specialized lasers (typically CW) used for studying and manipulating individual cells in biological systems. These lasers provide precise control and targeted energy delivery to enable various cellular analysis and manipulation techniques, providing researchers with powerful tools to explore cellular processes, understand cellular functions, and investigate disease mechanisms. These lasers offer precise control, high resolution, and versatility, enabling advancements in areas such as cell biology, neuroscience, regenerative medicine, and drug discovery. Common applications within this group include confocal fluorescence microscopy, DNA sequencing, flow cytometry, optogenetics, and more.

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Molecular Manipulation & Analysis Applications

Confocal Fluorescence Microscopy Lasers: Confocal microscopy is an optical technique that allows for extremely high spatial resolution imaging by placing two conjunct pinholes in the optical path. Most of the visible wavelengths can be used in confocal fluorescence microscopy, but it’s essential that all confocal fluorescence microscopy lasers (typically CW, low noise, single-mode, visible) have a high quality TEM00 beam profile.

DNA Sequencing Lasers: DNA sequencing or genome sequencing is an extremely powerful tool that allows the identification of the four basic DNA molecules adenine (A), cytosine (C), guanine (G), and thymine (T) by tagging them with fluorescence reporter molecules. Like all fluorescence applications, most of the visible wavelengths can be used in DNA sequencing, but it’s essential that all DNA sequencing lasers (typically CW, low noise, single-mode, visible) have a high quality TEM00 beam profile.

Flow Cytometry Lasers: Flow cytometry is a laser-based technology employed in cell counting, cell sorting, biomarker detection, and protein engineering. This technology is used to analyze the physical and chemical characteristics of particles in a fluid as it passes through at least one laser. Flow cytometry lasers (typically CW, low noise, single-mode, visible or IR) provide a high-quality TEM00 beam profile, low noise, and high pointing stability and power stability.

Optogenetics Lasers: Optogenetics is a biological technique that uses light to control cells in living tissue, typically neurons. While very little optical power is needed, optogenetics lasers (typically ns ps or fs pulsed, visible) are still the preferred delivery method because of their ability to be focused and targeted to specific areas of the brain.  Additionally, several wavelengths in the near-infrared region allow optogenetics lasers to be transmitted through bone and tissue eliminating the need for opening the skull.

Two-Photon Excitation Microscopy: Often called two-photon microscopy (2-photon, multi-photon, TPE microscopy), this process creates fluorescence images of live cells utilizing ultrashort pulsed lasers (typically mode-locked, fs pulsed lasers with NIR wavelengths). Compared to the usual one-photon microscopy, this method offers many benefits, such as better signal-to-noise ratio for clearer images, reduced photobleaching and phototoxicity, and deeper penetration in dense tissues.

Recommended Laser Series

We recommend the following laser series options for Molecular Manipulation & Analysis applications. There can often be a ton of options and many variables. Contact us today for help finding the perfect laser for your specific application!

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Matchbox Series

R1Z4-Matchbox Laser

The Matchbox series offers excellent performance and reliability in the “World’s Smallest” ultra-compact, all-in-one, integrated laser head. They can operate on a 5V power supply while maintaining low noise operation. The monolithic design of the Matchbox Series laser includes thermally stabilized optics in a hermetically sealed housing, ensuring reliable and maintenance-free operation. This series is available in wavelengths from 405 nm thru 1064nm, with options for collimated beam or fiber-coupled output, and single-mode and multimode versions.

Halite 2 Series

The Halite 2 series is a compact, single-box, all-fiber femtosecond laser designed to meet the most demanding applications in neuroscience, biophotonics, microscopy, and engineering. With pulses as short as <250 fs (< 100 fs op.), average power over 2 W at 1030 nm, and the option of second harmonic at 515 nm, it is an irreplaceable tool in every lab that needs a reliable, turn-key, ultrafast light source. Thanks to its unique construction and SESAM-free technology, it is a cost-effective solution that provides high pulse energy (over 100 nJ), excellent beam quality, and easy integration.

HL Series

TG420

The HL Series offers versatile and high-quality laser diode products in a variety of wavelengths and high-power options, ideal for direct imaging, industrial, and bio/medical applications. These reliable, efficient, and compact diodes come in TO-Can packages, making them perfect for OEM integration. Additionally, they operate with TE mode oscillation and are RoHS compliant, ensuring safe use. Choose the HL Series for quality, reliability, and performance in laser diodes. 

Jasper Series

The Jasper series is a diverse set of high-performance femtosecond fiber lasers providing different solutions based on a standard technology. The series includes the high-power Jasper X0 (200 µJ pulse energy / 60 W average power), the compact Jasper Micro (5 µJ pulse energy / 7 W average power) in a space-saving design, and the Jasper Flex for microprocessing (30 µJ pulse energy). Each model provides a fast warm-up time, long-term stability, and hands-free operation. Whether you need high power, compactness, or specific processing capabilities, the Jasper series has a solution.

JDL Series

Unmounted Laser Diodes Unpackaged Laser Diodes - gold bars laid out on a grid in a black gel pak

The JDL series offers industry-leading custom high-power unmounted laser diode bars in the 760-1070 nm spectral region. Our unmounted laser diode bars are available in a wide range of emitter configurations, cavity lengths, and CW or QCW operational modes. We offer low fill factor bars suitable for fiber coupling, high-power bars up to 300W for CW or hard-pulse industrial DDL applications, and QCW bars up to 500W for QCW or long-pulse optical pumping and medical applications. With full customization options including custom designed epitaxial wafer structures, you’re sure to get the perfect solution for your needs.

LaserBoxx Low Noise Series

The LaserBoxx Low Noise series of CW diode laser modules & DPSS lasers offer wavelengths from 375 to 1064nm, output powers up to 500 mW, and OEM & plug-&-play modules. These rugged, compact & highly customizable lasers also offer excellent beam quality & stability, modulation capabilities, ultra-low noise output & options for SM, MM, and PM fiber coupling. Our dedicated control software, USB and RS232 interfaces, and external controller with power display make integration, operation, and remote diagnostics a breeze.

LaserBoxx SLM Series

The LaserBoxx-SLM series of SLM CW DPSS & diode laser modules are available in wavelengths from 532-1064 nm, delivering ultra-narrow line widths with excellent temperature stability and low noise current. Embedded firmware locks the laser on the same mode at each startup. This customizable, compact laser module is available in turn-key or OEM versions, with GUI for remote operation & diagnostics via USB, RS232, or direct I/O interface, with modulation capabilities and adjustable power options.

LDX Series

The LDX Series of made-in-the-US, high-power, multimode laser diodes provide wavelengths from 400nm – 1900nm, a wide range of output powers and package types, as well as completely customized solutions. We have been offering these high-quality laser diodes for over 25 years. The performance, reliability, and lifetimes are time tested, and if for some reason there is an issue, we will make it right. 

LXCc Series

R2Z3-L4Cc Combiner

The LXCc series is a range of compact, highly customizable, and flexible all-in-one laser combiners that provide the widest variety of wavelength options, up to 7 different laser lines (up to 500 mW output power per line), direct modulation on every source, SLM capabilities, proven long-term stability, and many other advanced features. The turnkey or OEM versions allow a large choice of lasers from 375nm up to 1064nm. The extension module provides the ultimate level of flexibility with options for up to 4 optical fiber outputs, AOTF modulator, motorized ND filter, integrated fast switching output ports for FRAP, or adjustable split power for light-sheet microscopy. 

Q-SHIFT Series

Q-Shift SeriesThe Q-SHIFT series of Q-switched DPSS lasers is designed for researchers and application specialists working in micromachining, dermatology, LIDAR, time-resolved laser spectroscopy, and LIBS applications. With its built-in nonlinear wavelength conversion stage, this series can produce unconventional DPSS wavelengths: 1163, 1177, 1300, 1317, 1551 & 1571 nm. The optional harmonics generator can generate up to the 4th harmonic for each fundamental wavelength, providing even more versatility. This series can produce up to 40mJ/1W @ 1163nm with up to 100Hz repetition rate.

Q-Spark

Quantas-Q-SPARK-266: High energy, compact, nanosecond, DPSS laser

The Q-SPARK series is an air-cooled, diode-pumped, Q-switched laser designed for researchers and application specialists working with ablation, LIDAR, remote sensing, and LIBS applications. The laser produces sub-nanosecond or nanosecond pulses with peak power up to 20 MW and pulse energies up to 20 mJ, making it ideal for a wide range of applications. With a short pulse (<800 ps to <2 ns), compact air-cooled package, and innovative water-free laser crystal end-pumping technology, the Q-SPARK series delivers high-quality, low divergence, Gaussian-like laser beams.

Q-TUNE-HR Series

sleek, modern, light grey colored OPO & DPSS laser housingThe Q-TUNE-HR series is a high repetition rate OPO producing a tunable wavelength range from ≈ 750 – 1800 nm and up to 100 kHz pulse repetition rate, the perfect coherent light source for micromachining, Raman spectroscopy, microscopy, and remote sensing applications. Q-TUNE-HR requires an external pump source with > 350 μJ pulse energy and 5 – 7 ns FWHM pulse duration @ 532 nm for operation: pulse repetition rate can be in 10 – 100 kHz range and acceptable pump power in the 3.5 – 30 W range. By default OPO is optimized to produce maximum output in 1200 – 1800 nm range (optional: 750 – 950 nm). In addition to the tunable range, the pump laser wavelength is accessible through a convenient bypass port.

Q-TUNE-IR Series

Q-TUNE-IRThe Q-TUNE-IR series is the perfect high peak power, coherent DPSS light source for researchers with infrared spectroscopy applications. This series uses an Optical Parametric Oscillator (OPO) to produce a tunable wavelength of 1380–4500nm (<10 cm-1 linewidth), achieving > 15mJ of pulse energy at the peak of the tuning curve. The Q-TUNE-IR requires little maintenance, with all laser electronics integrated into the housing, including an air-cooling system, eliminating the need for chillers or large power supplies while providing a guaranteed > 2 G shot pump diode lifetime.

Q-TUNE Series

Q-TUNE-IR

The Q-TUNE series is a highly efficient, air-cooled, tunable wavelength laser, providing up to 8mJ, shorter than 5ns pulses at up to 100Hz, designed for temporally resolved spectroscopy, metrology, photo-acoustic imaging, and remote sensing applications. This laser uses an optical parametric oscillator (OPO) to produce a tunable wavelength range of 410-2300 nm with a linewidth narrower than 6 cm-1, which can extend to 210-410 nm with an optional second harmonic generator. Options for air purging for UV optics, spectrometer, and fiber-coupled OPO output are also available.

Q1 Series

Quantas-Q1-211: High energy, compact, nanosecond, DPSS laser

The Q1 series is a compact, energy-efficient, diode pumped, air-cooled, Q-switched laser available with up to 32 mJ at 1064 or 40 mJ at 1053nm @ 10 Hz, and rep rates up to 50Hz. The high peak powers and low divergence of the Q1 series enable efficient harmonic conversion through the 5th harmonic (213 or 211nm). The innovative design results in a user-friendly, turnkey system that requires little maintenance, and the laser’s variable pulse repetition rate and built-in sync pulse generator provide flexibility for triggering user equipment.

Q2 Series

Quantas-Q2-1064: High Energy, Compact, Nanosecond, DPSS Laser

The Q2 series is a diode-pumped, air-cooled, Q-switched laser emitting at 1064 or 1053nm, designed for a wide range of applications that require high peak power pulses. The water-free end-pumping technology produces high peak powers and low divergence, enabling efficient harmonics conversion through the 5th harmonic (213 or 211nm). This versatile platform can be configured in many ways, including up to 80mJ pulse energy at 10 Hz pulse repetition rate or up to 20mJ at 100 Hz. In the short cavity configuration, pulse duration can be reduced by 50% compared to the standard configuration.

RWLD Series

The RWLD series offers competitively priced laser diodes with high beam quality and a wide variety of products to support multiple applications. Available in a wide range of wavelengths, power levels, and packages. The RWLD wavelength options span from 405nm to 1650nm, with output powers in the range of 10 mW to 300 mW, packaged in a TO-18 package with photodiode. We also offer customized options, such as a customized wavelength, output power, or a special package to meet your specific needs.

RWLP Series

R3Z0-WSLP-905-050m-M-PD: 905nm Multimode Fiber Coupled Laser Diode

The RWLP series offers an affordable and versatile solution for your laser application needs with single-mode and multimode options and wavelengths from 405nm thru the IR region. With customizable options, our team can work with you to solve any challenges you may face. Rigorously tested for long-term reliability, the RWLP series ensures consistent performance and high beam quality. Perfect for integration, this series supports multiple applications including biological and analytical instrumentation. 

SL-Pico Series

sleek modern dpss laser housing, simple cubic design, black and red with optical fiber & connectorThe SL-Pico series of picosecond supercontinuum lasers is designed to meet the diverse and dynamic needs of cutting-edge research and industrial applications. These supercontinuum white lasers are highly regarded for their wide wavelength range and cost-effectiveness. The SL-Pico offers a spectral range from 410 to 2400 nm, has high power, is very stable, and is capable of delivering power up to 8 W. The SLM versions are mode-locked fiber lasers with a fixed rep. rate, and the SLMV versions have a tunable repetition rate (up to 40 or 200 MHz), ensuring compatibility with a wide range of devices and various applications like fluorescence microscopy, TCSP, hyperspectral imaging, semiconductor inspection, and much more!

SOL Series

simple, compact OEM pulsed laser housing with cooling fan and f-theta lens

The SOL series is the most compact, air-cooled, Q-switched DPSS nanosecond industrial laser solution available with output power up to 60W @ 1064nm, designed for thin film removal, marking, and PCB repair applications. With its excellent beam quality, high peak power, wavelength options (1064, 532 & 355 nm), PRR from single shot up to 200 kHz, optional CW configuration, customization options, and a wide range of add-ons, this series is an excellent solution for OEM integrators, application specialists, and researchers. With attractive pricing (especially volume pricing) and a rugged, compact, lightweight, and easy-to-use single-unit design, the SOL laser is easy to integrate into any system, providing superior operational flexibility and performance/cost ratio.

TG Series

R1Z5-TG420

The TG Series of laser diodes emit in the blue spectral range with non-standard wavelengths from 418 nm up to 466 nm, perfect for Life Science applications, with a typical output power of 50mW and an absolute maximum output power of 100mW. Assembled in a 5.6 mm (TO-56) packages the TG series is a suitable for a wide range of OEM applications that require blue/violet light, including ECDL with low AR coating option.

TLS Series

sleek modern dpss laser housing, simple cubic design, black and redThe TLS series is the broadest continuously optically tunable broadband picosecond laser combining a supercontinuum laser & tunable bandpass filter. Users can tune output power, wavelengths from 410-1700nm by choosing the VIS, IR, SWIR, or a custom configuration, and real-time bandwidth control for TLS-Red (10 or 20nm fixed for TLS-Blue). These picosecond tunable lasers are suitable for various fields that require precision scanning and high output from fluorescence microscopy to time-resolved spectroscopy, such as TCSPC, Hyperspectral imaging, Machine vision, Semiconductors, Sensors, and other applications.

Wedge Series

metal pulsed laser housing, gray metal, cooling fins, output port

The Wedge series of DPSS lasers is a rugged industrial solution, designed for seamless integration into OEM micromachining, LIDAR, and LIBS end-user systems. Based on proprietary fast Q-switching technology, this series is compact, sealed, and monolithic, making them insensitive to vibrations & harsh environments. High peak powers, relatively low energy, and low heat generation allow efficient ablation and non-linear interaction. Available from 266 nm to ≈ 3 µm, up to 4 mJ pulse energy @ 1064, and up to 4 MW peak power, the lightweight, air-cooled package benefits LIDAR and aerospace applications, while short pulses provide exact time-of-flight measurements. Many optional add-ons and customization options.