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Imaging & Analysis Lasers
What are Imaging and Analysis Lasers?
Imaging & Analysis Lasers refer to advanced laser systems (typically pulsed) used in the research and biophotonics markets for various applications. These lasers are specifically designed for precise imaging and analysis techniques, enabling researchers to study and understand complex biological processes. They offer capabilities for fluorescence lifetime imaging, Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-ToF) mass spectrometry, and particle image velocimetry (PIV), among others. By providing tailored laser sources and specific parameters suitable for each application, imaging & analysis lasers facilitate high-resolution imaging, biomolecular analysis, and fluid flow measurements. These lasers play a crucial role in advancing research in areas such as biology, medicine, and fluid dynamics, contributing to scientific discoveries and advancements in various fields.
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Imaging & Analysis Applications
Fluorescence Lifetime Lasers: Fluorescence lifetime imaging microscopy (FLIM) is a method used for measuring the time a molecule spends in the excited state. Typical lifetimes are on the order of a few picoseconds to hundreds of nanoseconds depending on the molecule, therefore ultra-short pulses in the picosecond or femtosecond range are required from fluorescence lifetime lasers.
Maldi-ToF Lasers: Maldi ToF is a method used in mass spectrometry for measuring the time it takes for ionized particles of different masses to drift to the detector. For this process to work, there must be a mechanism in place to ionize the particles (e.g., photoionization). This technique traditionally uses high pulse energy q-switched ultraviolet lasers (typically ns or ps pulsed, UV, green, or IR microchip lasers), because the photon energy must be greater than the ionization energy of the particle.
Particle Image Velocimetry Lasers: Particle Image Velocimetry (PIV) is an experimental method used for determining the velocity of a flowing fluid by monitoring the particles in the stream which are illuminated by a laser. For this application to work, particle image velocimetry lasers and cameras must be time-gated and triggered at the same time so that each image can be precisely mapped to a point in time. Typically, 532nm pulsed DPSS lasers are utilized, but any pulsed visible laser should work.
Recommended Laser Series
We recommend the following laser series options for Imaging & Analysis applications. There can often be a ton of options and many variables. Contact us today for help finding the perfect laser for your specific application!
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The MicroMake Series is a fully-integrated, compact, sub-ns DPSS laser micromachining system for high precision and resolution applications. A flexible platform at 532 & 266 nm, with >40 kW of peak power and processing speeds up to 100mm/second, the system includes all the needed devices for direct laser micro-processing in a single, monolithic, air-cooled configuration. Equipped with a live microscope, alignments and in-process quality checks are a breeze. All these features perfectly suit various materials utilized in microelectronic circuits, displays fabrication and correction, biomedical device machining and optical substrates microprocessing.
The Q-DOUBLE series is a DPSS, air-cooled, q-switched laser at 1064 or 1053 nm, designed to produce two pulses with variable temporal separation for PIV, LIBS, and other applications. The Q-DOUBLE can be configured for up to 160 mJ pulse energy @ 10 Hz or up to 40 mJ @ 100 Hz. The innovative laser design integrates all electronics (except power adapter) into the housing, resulting in a compact, user-friendly, turnkey, and air-cooled (water-free) system requiring little maintenance. User-friendly web-based GUI allows remote monitoring, control, and support from any computer or even a smartphone. Optional add-ons include built-in 2nd, 3rd, or 4th harmonic generator, built-in attenuator, energy monitor, and optional short cavity version.
The Q-TUNE-HR series is a high repetition rate OPO producing a tunable wavelength range from ≈ 750 – 1800 nm and up to 100 kHz pulse repetition rate, the perfect coherent light source for micromachining, Raman spectroscopy, microscopy, and remote sensing applications. Q-TUNE-HR requires an external pump source with > 350 μJ pulse energy and 5 – 7 ns FWHM pulse duration @ 532 nm for operation: pulse repetition rate can be in 10 – 100 kHz range and acceptable pump power in the 3.5 – 30 W range. By default OPO is optimized to produce maximum output in 1200 – 1800 nm range (optional: 750 – 950 nm). In addition to the tunable range, the pump laser wavelength is accessible through a convenient bypass port.
The Q-TUNE-IR series is the perfect high peak power, coherent DPSS light source for researchers with infrared spectroscopy applications. This series uses an Optical Parametric Oscillator (OPO) to produce a tunable wavelength of 1380–4500nm (<10 cm-1 linewidth), achieving > 15mJ of pulse energy at the peak of the tuning curve. The Q-TUNE-IR requires little maintenance, with all laser electronics integrated into the housing, including an air-cooling system, eliminating the need for chillers or large power supplies while providing a guaranteed > 2 G shot pump diode lifetime.
The SL-Pico series of picosecond supercontinuum lasers is designed to meet the diverse and dynamic needs of cutting-edge research and industrial applications. These supercontinuum white lasers are highly regarded for their wide wavelength range and cost-effectiveness. The SL-Pico offers a spectral range from 410 to 2400 nm, has high power, is very stable, and is capable of delivering power up to 8 W. The SLM versions are mode-locked fiber lasers with a fixed rep. rate, and the SLMV versions have a tunable repetition rate (up to 40 or 200 MHz), ensuring compatibility with a wide range of devices and various applications like fluorescence microscopy, TCSP, hyperspectral imaging, semiconductor inspection, and much more!
The TLS series is the broadest continuously optically tunable broadband picosecond laser combining a supercontinuum laser & tunable bandpass filter. Users can tune output power, wavelengths from 410-1700nm by choosing the VIS, IR, SWIR, or a custom configuration, and real-time bandwidth control for TLS-Red (10 or 20nm fixed for TLS-Blue). These picosecond tunable lasers are suitable for various fields that require precision scanning and high output from fluorescence microscopy to time-resolved spectroscopy, such as TCSPC, Hyperspectral imaging, Machine vision, Semiconductors, Sensors, and other applications.